Abstract
2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potential activities.
Highlights
The main objective of organic and medicinal chemistry is the design, synthesis, and production of molecules having value as human therapeutic agents
Heterocyclic structures received special attention as they belong to a class of compounds with proven utility in medicinal chemistry
Suresh: active bicyclic molecules containing two hetero atoms. 2-Mercaptobenzothiazole (MBT) (1, Figure 1) is an important scaffold known to be associated with several biological activities, and its derivatives are manufactured worldwide for a wide variety of applications
Summary
Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India. © Azam and Suresh; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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