Biological Activities and Therapeutic Potential of Irigenin on Gastric, Lung, Prostate, Breast, and Endometrial Cancer: Pharmacological and Analytical Aspects

Abstract

Background: Herbal medicine has been in used in the medicine for thousands of years due to its multiple pharmacological activities against different types of human disorders. Biological effectiveness and pharmacological activities of herbal medicines is mainly due to the presence of different kinds of phytoconstituents commonly called secondary metabolites. Isoflavones are naturally present in different types of plants and food materials and most of these phytocompounds have a wide range of biological activities including anti-tumor, anti-proliferative, anti-inflammatory, anti-microbial, anti-viral, anti-oxidant, and estrogen-like activities. Methods: Irigenin isolated from the rhizome of Belamcanda chinensis and the genus Iris showed a wide range of biological activities. Due to huge biological potential and the therapeutic benefit of irigenin in the medicine, here in the present investigation, scientific research data of irigenin has been collected from different literature sources (Science Direct, Google Scholar, PubMed, Google) and analyzed in order to know the therapeutic potential of irigenin in the medicine. Pharmacological activities scientific data of irigenin have been collected from Science Direct, Google Scholar, PubMed, Google databases and analyzed in the present work. Importance of different analytical techniques for isolation and separation of irigenin has been also discussed and presented in the present work. Results: Scientific data analysis of different research work revealed the biological importance of irigenin in the medicine. Irigenin is an O-methylated isoflavone found to be present in the Belamcanda chinensis and genus Iris. Scientific data analysis revealed the biological importance of irigenin against gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation and cardiac injury. Analytical data of irigenin revealed the importance of analytical techniques for the separation, isolation and identification of irigenin from various biological samples. Conclusion: Scientific data analysis of different research works revealed the biological importance and therapeutic potential of irigenin in the medicine.