Abstract
In our search into biological activity and chemical profiling of Indonesian medicinal plants, phytochemicals and biological of Hyptis capitata grown at two location in East Kalimantan, Indonesia, were investigated. Leaves of H. capitata collected from location 1, Samarinda (coded by HSM) and location 2, West Kutai areas (coded by HWK) were macerated using ethanol. The plant was evaluated its biological activities in terms of antimicrobial and antioxidant activity, and cytotoxicity against Artemia salina, while phytochemicals were analyzed by qualitative and quantitative tests. The results showed that leaves extract of H. capitata contain alkaloids, flavonoids, tannins, carbohydrates and coumarins. HSM possessed higher phenolic and flavonoid content than that of HWK. HWK displayed more antimicrobial activity against the test microorganisms particularly P. acnes (29%), S. sobrinus (49%), S. aureus (51%) and E. coli (45%). HSM showed more radical scavenging activity in DPPH (IC50 13.69 µg/ml) and superoxide (IC50 65.11 µg/ml) tests. Brine shrimp lethality test showed no toxicity of H. capitata leaves extracts. The results suggested that biological activities and phytochemicals of Hyptis capitata were affected by the growing location represented the diferrent environmental factors including light intensity, temperature, soil nutrition and predatory risks.
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