Abstract
Summary A detailed study of the inhibition of the first component of human complement (C′1) by polyinosinic acid (poly I) has been presented. Less than 1 × 10-3 µmole poly I/ml will inhibit C′1 hemolytic activity in the liquid phase or attached to sensitized erythrocytes (EAC′1). Poly I incorporated into a double-stranded helix with polyadenylic acid does not inhibit C′1. Study of the effect of poly I on the isolated subcomponents of C′1 (C′1q, C′1r, C′1s) shows that poly I selectively inhibits C′1q. The inhibition of C′1 and C′1q by poly I is, to a variable extent, reversible by the subsequent addition of poly A. Of other synthetic polyribonucleotides only polyriboguanylic acid and mixed copolymers of inosinic and uridylic acids, or guanylic and uridylic acids having greater than 80% inosinic or guanylic acid content, display any Anti-C′1 activity.
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