Abstract
We have analyzed the biologic activity of supercoiled oligomeric forms of SV40 DNA during productive and transforming infection. These DNA molecules had equal infectivity as assayed by plaque formation; however, the ability of such DNA molecules to transform nonpermissive cells increased linearly with their size. Oligomeric linear and circular forms of SV40 DNA produced by in vitro ligation of linear SV40 monomeric DNA had similarly enhanced transforming activity. Nucleic acid hybridization studies suggest that the amount of viral DNA in rat cells transformed by the variously sized oligomeric DNAs is similar.
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