Abstract
Oral administration is a widespread and convenient drug delivery approach. However, oral delivery can be affected by the complex digestive tract environment, including irregular tissue morphology, the presence of digestive enzymes, mucus and mucosal barriers, and spatiotemporal variance in physiological parameters. These obstacles can prevent the oral delivery of many therapeutics. To overcome these challenges, oral delivery devices can be designed with bioinspired compositions, structures or functions to make more drugs available for oral administration. Various bioinspired oral delivery devices have been developed by harnessing biological materials and living microorganisms, or by imitating biological structures and functions. In this Review, we discuss the design and modification of bioinspired oral delivery devices, examining engineering strategies to target specific tissues and applications. We highlight how key bottlenecks in oral delivery can be addressed through bioinspired designs, concluding with an outlook on the remaining challenges towards the clinical translation of bioinspired oral delivery devices.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
