Abstract
In recent times, nanoparticles are attributed to green nanotechnology methods to know the synergistic biological activities. To accomplish this phenomenon, present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) by using Syzygium alternifolium stem bark, characterized those NPs using expository tools and to elucidate high prioritized antimicrobial and anticancer activities. Synthesized particles exhibited a color change pattern upon synthesis and affirmed its respective broad peak at 285 nm which was analyzed through UV–vis spectroscopy. FT-IR study confirmed that phenols and primary amines were mainly involved in capping and stabilization of nanoparticles. DLS and Zeta potential studies revealed narrow size of particles with greater stability. XRD studies revealed the crystallographic nature of particles with 17.2 nm average size. Microscopic analysis by using TEM revealed that particle size range from 5–13 nm and most of them were spherical in shape, non-agglomerated and poly-dispersed in condition. Antimicrobial studies of particles showed highest inhibitory activity against E. coli and T. harzianum among bacterial and fungal strains, respectively. The scope of this study is extended by examining anticancer activity of CuO NPs. This study exhibited potential anticancer activity towards MDA-MB-231 human breast cancer lines. Overall, these examinations relate that the S. alternifolium is described as efficient well-being plant and probabilistically for the design and synthesis of nanoparticles for human health. This study paves a way to better understand antimicrobial and anticancer therapeutic drug potentials of nanoparticles to design and analysis of pharmaceuticals by in vivo and in vitro approaches.
Highlights
In the present century research on nanotechnology gains much importance in the fields of biology, medicine, physics, chemistry and electronics
The analytical tools like UV–vis spectroscopy and FT-IR studies revealed that the reduction of nanoparticle by ascorbic acid and the presence of phytochemicals like phenols and primary amines of proteins become helpful in capping and stabilization of particles
This study concludes that the plant S. alternifolium is an excellent green source for synthesis of copper oxide nanoparticles
Summary
In the present century research on nanotechnology gains much importance in the fields of biology, medicine, physics, chemistry and electronics. When coming to the biology nanoparticles are synthesized with the help of medicinal plants as reducing agents and is a fascinating research area by synthesizing different types of nanoparticles like, calcium, copper, gold, iron, silver and zinc (Kumar et al 2016). In chemical-mediated synthesis, the copper salts were reduced with the help of reducing agents like, sodium borohydride, hydrazine, microemulsions and with evaporation/condensation methods. Flammable inorganic compound, exposure to this chemical cause irritation of eyes, nose and throat. The evaporation/condensation method occupies large space, consumes more power and the obtained powders were in highly agglomerated state. These nano-powders were treated with high purity gas streams to cause compositional and structural modifications of nanoparticles, which arises hazardous waste materials to the environment (Tavakoli et al 2007)
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