Bioinformatics Tools to Understand Notch.

Abstract

As a result of the culmination of data, and the fast-paced advancement of new research, all the biological information collected can make it difficult to sort data. This is oftentimes experienced when learning about the human genome. Fortunately, with the advancement of technology, the field of bioinformatics has emerged which has allowed for the creation of a variety of biological databases. These biological databases provide a condensed reservoir of organized information that is easy to use and topic-specific. Here, we provide a list of 39 biological databases that help break down the fundamental details of a gene. This chapter uses the NOTCH1 gene as an example to demonstrate how biological databases can be used to extract gene information. Five sections were created to highlight the major areas needed to build a comprehensive foundation of NOTCH1. The first section lists databases containing basic gene and protein product information. The next section consists of protein interactions and signaling pathway databases which are essential in understanding the biological processes a gene product is involved in. Gene expression and disease databases are the next two sections which are connected since disease results from the aberrant expression of a gene product. The last database section examines model organisms which serve a key role in the study of human genetic diseases. Using these databases, we can elucidate NOTCH1's gene/protein structure, expression, and vital physiological function through the Notch signaling pathway.