Bioinformatics Approach for Finding Target Protein in Infectious Disease

Abstract

AbstractWith the technological advancements, biological data pertaining to various infectious organisms is getting abundant. This copiousness has been useful for developing abysmal understanding of the complex biological process which leads to the diseased condition in human race. Existing mode of treatments for such infectious diseases currently faces various challenges such as drug resistance. Thus, identification of new drug targets has become one of the major objectives of the scientific community involved in drug designing. These novel drug targets can provide effective know-how of the infectious organisms in order to develop novel therapeutic agents in order to contain the spread of the disease. Systems biology approach has been considered as one of the promising approach that can effectively lead to novel drug target identification. It provides the conceptual framework for the analysis using the amalgamation of variety of data obtained from conglomeration of advanced molecular biology techniques. In this chapter, we have elaborated the systems biology approaches which can be used for identification of novel drug targets for various infectious diseases. Apart from emphasizing systems biology leads in the area of drug target identification, we have highlighted some in silico experiments performed using these techniques for the identification of novel drug targets in infectious organisms such as P. falciparum and M. tuberculosis. This chapter might help in devising the effective systems biology strategies in order to develop hypothesis toward identification of novel drug targets.KeywordsDrug targetsSystems biologyConceptual frameworkAmalgamationInfectious diseasesIn silico experiments