Abstract
Background: Tripartite motif 13 (TRIM13) plays a significant role in various biological processes including cell growth, apoptosis, transcriptional regulation, and carcinogenesis. However, the prognostic significance of TRIM13 gene in breast cancer treatment remains largely unclear. Methods: We performed a bioinformatics analysis of the clinical parameters and survival data as it relates to TRIM13 in breast cancer patients using several online databases including Oncomine, bcGenExMiner, PrognoScan, and UCSC Xena. Results: We found that TRIM13 was lower-expressed in different subtypes of breast cancer with respect to normal tissues. Estrogen receptor and progesterone receptor status were positively correlated with TRIM13 level; whereas, the Scarff–Bloom–Richardson grade, Nottingham prognostic index, nodal status, basal-like status, and triple-negative status were negatively related to TRIM13 expression in breast cancer patients with respect to normal individuals. Lower TRIM13 expression correlated with worse distant metastasis free survival, relapse free survival, disease specific survival, and metastatic relapse free survival. We also confirmed a positive correlation between TRIM13 and RAB11FIP2 gene expression. Conclusion: Bioinformatics analysis revealed that TRIM13 may be adopted as a promising predictive biomarker for prognosis of breast cancer. More in-depth experiments and clinical trials are needed to validate the value of TRIM13 in breast cancer treatment.
Highlights
Breast cancer remains the most common malignant tumor and a leading cause of cancer-related mortality in women worldwide [1]
Accumulated evidence has suggested that some members of tripartite motif (TRIM) are involved in various biological processes including cell growth, apoptosis, transcriptional regulation, and carcinogenesis [4]
Tripartite motif 13 (TRIM13) over-expression caused stabilization of p53 and decrease of Akt kinase activity followed by induction of apoptosis [17]. These findings suggest that TRIM13 may function as a tumor suppressor, and as a potential predictive biomarker for prognosis of cancer
Summary
Breast cancer remains the most common malignant tumor and a leading cause of cancer-related mortality in women worldwide [1]. Accumulated evidence has suggested that some members of TRIM are involved in various biological processes including cell growth, apoptosis, transcriptional regulation, and carcinogenesis [4]. TRIM36 played a tumor suppressive role by reducing cell proliferation and migration as well as promoting apoptosis in prostate cancer [6]. Tripartite motif 13 (TRIM13) plays a significant role in various biological processes including cell growth, apoptosis, transcriptional regulation, and carcinogenesis. The prognostic significance of TRIM13 gene in breast cancer treatment remains largely unclear. Estrogen receptor and progesterone receptor status were positively correlated with TRIM13 level; whereas, the Scarff–Bloom–Richardson grade, Nottingham prognostic index, nodal status, basal-like status, and triple-negative status were negatively related to TRIM13 expression in breast cancer patients with respect to normal individuals. More in-depth experiments and clinical trials are needed to validate the value of TRIM13 in breast cancer treatment
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