Bioinformatics analysis of BMPR1B gene in different species

Abstract

Multiple-births is one of the most animals important trait. Many genetic and environmental factors affect on multiple-births. Bone morphogenetic protein receptor IB (BMPR-IB) is one of the genetic factors affecting this trait in sheep. In this study, 72 different sequences were extracted from NCBI and then some bioinformatics analysis were investigated such as CDS length, stop codon variation, homology search, molecular mass, signal peptide, isoelectric point, tertiary structure, transmembrane, motifs and phylogenetic tree. This gene has been had 4 motifs such as Activin_recp, transmembrane, GS motif and STYKc Protein kinase. Also the results were indicated that BMPR1B in sheep has closely relationship with goat and cow. Multiple alignment showed high conservation of motifs which indicate constancy of this gene during evolution. The results of this study can be used to better recognition of BMPR-1B gene structure in different animals which would be helpful for animal breeding plans.