Abstract
Glioblastoma (GBM) has long been a major clinical research challenge to scientists. The pivotal role of the mitochondria related gene family in the promotion of GBM tumorigenesis is not clear. We detected that microtubular tubulin beta 6 class V (TUBB6) was one of 33 differentially expressed mitochondrial-focused genes (DEMFGs) in GBM, and considered that TUBB6 is a potential therapeutic target in GBM. TUBB6 was vital for GBM and marked as the key prognostic gene in primary GBM. Mutations of TUBB6 in GBM were rare. Only four TUBB6 co-expressed hub genes (ANXA2, S100A11, FLNA, and MSN) exhibited poorer overall survival rates in higher expression groups (p-value < 0.05). We have confirmed the up-regulation of TUBB6 and its partners, ANXA2 and S100A11 in GBM and validated their importance as prognostic factors in primary GBM. TUBB6 was significantly correlated with stromal score in GBM samples (p-value = 6.99E-04). This study aimed to assess the importance of novel hub genes by analyzing the expression, potential function and prognostic impact of TUBB6 in human primary GBM cancer.
Highlights
Reliable biomarkers have been the subject of many classic studies in cancer research (Salamone et al, 2018)
EdgeR packages (Figure 2A), 18 differentially expressed mitochondrial-focused genes (DEMFGs) were up-regulated and 15 DEMFGs were down-regulated according to their q-value < 0.05 and log2FoldChange >2 (Figure 2B)
To determine the biological significance of DEMFGs, the chord diagram for GO terms and Kyoto encyclopedia of genes and genomes (KEGG) pathway were determined by GOplot (Figure 3)
Summary
Reliable biomarkers have been the subject of many classic studies in cancer research (Salamone et al, 2018). Pan-cancer research can play a pivotal role in the development of diagnosis, treatment plans and novel therapeutics (Gizem et al, 2020). Gliomas [ependymoma, astrocytoma, oligodendroglioma, brainstem glioma, and glioblastoma (GBM)] are malignant brain tumors. The median patient survival time for GBM patients is only 15 months. Glioblastoma has the highest incidence of all gliomas and is the most malignant (stage 4) on the World Health Organization’s (WHO) scale of severity (Zhao et al, 2020). Palliative treatments include surgery, radiotherapy and chemotherapy. In China, the annual incidence of GBM was 5–10 million new patients per year
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