Abstract
Objective: A systematic assessment of taijiquan fitness effects from an immunological perspective, with the aid of bioinformatics analysis. Methods: Bioinformatics as a means of analysis, including mainly: Gene Set Enrichment Analysis (GSEA analysis), GO pathway enrichment and PPI network integration to systematically analyse the target data sources (RNA-Seq data from Parkinson's patient population after 12 weeks of TCC and MET exercise) in the GEO database; Results: The TCC group significantly increased the expression of primary T cells relative to the MET group; it effectively increased the number of human CD8+ T and NK cells. human neutrophils were highly expressed in the MET group; TCC may activate more T cells, especially CD8+ and NK cells, by activating aerobic metabolic pathways in the body, whereas MET activates the expression of neutrophils and monocytes. TCC movement enhances the function of mitochondria in immune cells through respiration, which in turn further activates T cell proliferation through epigenetic modifications that move. Conclusion: TCC exercise is effective in boosting the body's acquired adaptive immunity, while MET exercise stimulates the activity of the body's innate immunity, making TCC more suitable for health and wellness, especially for the chronic patient population.
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