Abstract
Bioinformatics Analysis and Identification of the Expression and Mechanism of Immune-Related Gene MAPT in Hepatocellular Carcinoma
Highlights
Hepatocellular carcinoma (HCC) is the most common malignancy with a high mortality rate in many parts of the world 1
microtubule-associated protein tau (MAPT) expression comparison A meta-analysis of MAPT expression in 5 analyses with verge values was determined as p-Value 0.05, fold change >1, and the top 10% gene rank in the Oncomine database was performed in our research
The findings have shown that the expression levels of MAPT mRNA were significantly higher in human HCC samples than those in the non-tumor samples (Figure 2A)
Summary
Hepatocellular carcinoma (HCC) is the most common malignancy with a high mortality rate in many parts of the world 1. During the last few decades, significant advances have been achieved in understanding the epidemiology, risk factors, and molecular mechanisms in HCC 2. The annual mortality rate associated with HCC has increased substantially over the past two decades 3. Initial analyses, reported by Saif Zaman et al, suggested that a higher expression of MAPT associated with better overall survival in neuroblastoma 7. MAPT in HCC has been rarely discussed. Zhang developed and validated a prognostic nomogram to predict the overall survival of HCC patients, in which MAPT acts as a significant variable 8. Bioinformatics analysis by Qi revealed that MAPT serves as an upstream regulator of AMELY in HCC 9. The expression level, clinicopathological significance, and the biological functions and associated mechanisms of MAPT in HCC had not reported to date
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