Abstract
With advanced technology and its development, bioinformatics is one of the avant-garde fields that has managed to make amazing progress in the pharmaceutical–medical field by modeling the infrastructural dimensions of healthcare and integrating computing tools in drug innovation, facilitating prevention, detection/more accurate diagnosis, and treatment of disorders, while saving time and money. By association, bioinformatics and pharmacovigilance promoted both sample analyzes and interpretation of drug side effects, also focusing on drug discovery and development (DDD), in which systems biology, a personalized approach, and drug repositioning were considered together with translational medicine. The role of bioinformatics has been highlighted in DDD, proteomics, genetics, modeling, miRNA discovery and assessment, and clinical genome sequencing. The authors have collated significant data from the most known online databases and publishers, also narrowing the diversified applications, in order to target four major areas (tetrad): DDD, anti-microbial research, genomic sequencing, and miRNA research and its significance in the management of current pandemic context. Our analysis aims to provide optimal data in the field by stratification of the information related to the published data in key sectors and to capture the attention of researchers interested in bioinformatics, a field that has succeeded in advancing the healthcare paradigm by introducing developing techniques and multiple database platforms, addressed in the manuscript.
Highlights
Bioinformatics is a term that refers to the collection and evaluation of scientific data by employing computational techniques, integrating the biological information comprising of proteins, genes, cells, robotics, medical information, and ecosystems with technological mediums such as databases, software, tools, etc. [1,2,3]
Certain bioinformatics approaches and databases can be employed in translational studies associated with drug discovery and development, such as absorption of the drug, distribution profile, metabolic processes, excretion, and toxicity profile (ADMET) along with an integrated database for ADMET, as well as adverse effect predictive modeling (IDAAPM), which provides predictive designing, alongside evaluation and analysis of drug information provided by the Food and Drug Administration (FDA) [29]
Numerous natural compounds can be used to fight against such infections, on account of their antimicrobial properties, which are referred to as antimicrobial peptides (AMPs)
Summary
Bioinformatics is a term that refers to the collection and evaluation of scientific data by employing computational techniques, integrating the biological information comprising of proteins, genes, cells, robotics, medical information, and ecosystems with technological mediums such as databases, software, tools, etc. [1,2,3]. Bioinformatics is a term that refers to the collection and evaluation of scientific data by employing computational techniques, integrating the biological information comprising of proteins, genes, cells, robotics, medical information, and ecosystems with technological mediums such as databases, software, tools, etc. Numerous economical bioinformatics tools have been established as a result of accelerating technological advancements [5]. The conduct of clinical trials requires significant time and massive capital investment in introducing a drug into the market, thereby establishing a dire need for an economical approach to discover and develop drugs, followed by their overall assessment and evaluation [6]. The pharmacological therapies are available for only 30% of the diseases identified, as per the investigations [7], and many biological targets for numerous diseases are yet to be identified [8].
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