Abstract
The informational value of assessing biochemical markers in the gingival fluid of patients with various systemic and local changes in bone tissue was analyzed in a sample of 57 patients and 15 healthy people. The patients were differentiated into 3 groups: 1) 20 patients with ulcerative colitis and steroid osteoporosis due to glucocorticoid therapy; 2) 22 patients diagnosed with cancer of the mucous membrane of the floor of the mouth with erosions of the cortical bone or dental socket by a primary tumor; 3) 15 patients with moderate dental peri-implantitis. Gingival fluid was used as a test material. The content of cathepsin K, tartrate-resistant acid phosphatase, and bone fraction of alkaline phosphatase was determined. In steroidal osteoporosis, the cathepsin K level in the gingival fluid was found to be statistically significantly increased compared to other markers under study. In group 2, with tumor osteodestruction in the gingival fluid, a 10-fold increase in the concentration of cathepsin K and tartrate-resistant acid phosphatase was observed against the background of a moderate increase in the bone fraction of alkaline phosphatase content. In osteodestruction associated with inflammatory dentoalveolar processes, a moderate increase in the concentration of cathepsin K and tartrate-resistant acid phosphatase was observed. Thus, the determination of osteomarkers in the gingival fluid can be considered informative in terms of distinguishing between systemic and local changes in the structure of bone tissue.
Highlights
На 57 больных и 15 практически здоровых людях проанализирована информативность оценки био химических маркеров в десневой жидкости при системных и местных изменениях костной ткани различного генеза
The patients were differentiated into 3 groups: 1) 20 patients with ulcerative colitis and steroid osteoporosis due to glucocorticoid therapy; 2) 22 patients diagnosed with cancer of the mucous membrane of the floor of the mouth with erosions of the cortical bone or dental socket by a primary tumor; 3) 15 patients with moderate dental peri-implantitis
The cathepsin K level in the gingival fluid was found to be statistically significantly increased compared to other markers under study
Summary
На 57 больных и 15 практически здоровых людях проанализирована информативность оценки био химических маркеров в десневой жидкости при системных и местных изменениях костной ткани различного генеза. В группе 2 при опухолевой остеодеструкции в десневой жидкости наблюдался десятикратный прирост концентрации катепсина К и ТРКФ на фоне умеренного повышения содержания костной фракции щелочной фосфатазы. Определение остеомаркеров в десневой жидкости информативно для разграничения системных и местных изменений структуры костной ткани. Биоинформационный анализ уровня остеомаркеров в десневой жидкости при системном остеопорозе и местных остеодеструктивных процессах дентоальвеолярной области.
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