Abstract
Spinal cord injury (SCI) is often accompanied by muscle atrophy; however, its underlying mechanisms remain unclear. Here, the molecular mechanisms of muscle atrophy following SCI were investigated. The GSE45550 gene expression profile of control (before SCI) and experimental (14 days following SCI) groups, consisting of Sprague–Dawley rat soleus muscle (n = 6 per group), was downloaded from the Gene Expression Omnibus database, and then differentially expressed gene (DEG) identification and Gene Ontology, pathway, pathway network, and gene signal network analyses were performed. A total of 925 differentially expressed genes, 149 biological processes, and 55 pathways were screened. In the pathway network analysis, the 10 most important pathways were citrate cycle (TCA cycle), pyruvate metabolism, MAPK signalling pathway, fatty acid degradation, propanoate metabolism, apoptosis, focal adhesion, synthesis and degradation of ketone bodies, Wnt signalling, and cancer pathways. In the gene signal network analysis, the 10 most important genes were Acat1, Acadvl, Acaa2, Hadhb, Acss1, Oxct1, Hadha, Hadh, Acaca, and Cpt1b. Thus, we screened the key genes and pathways that may be involved in muscle atrophy after SCI and provided support for finding valuable markers for this disease.
Highlights
Spinal cord injury (SCI) is often accompanied by muscle atrophy; its underlying mechanisms remain unclear
No clear consensus exists regarding the classification of muscle atrophy after SCI
Some reports have suggested that muscle atrophy after SCI be classified as disuse atrophy or denervation atrophy[15,16,17,18]
Summary
Spinal cord injury (SCI) is often accompanied by muscle atrophy; its underlying mechanisms remain unclear. A total of 925 differentially expressed genes, 149 biological processes, and 55 pathways were screened. In the gene signal network analysis, the 10 most important genes were Acat[1], Acadvl, Acaa[2], Hadhb, Acss[1], Oxct[1], Hadha, Hadh, Acaca, and Cpt1b. We screened the key genes and pathways that may be involved in muscle atrophy after SCI and provided support for finding valuable markers for this disease. Spinal cord injury (SCI) is a major cause of disability in humans which can lead to muscle atrophy. Muscle atrophy affects the care management and activities of daily living for patients with SCI, and has significant effects on their health by increasing the risk of secondary complications, such as osteoporosis, diabetes, and cardiovascular d. Prevention of muscle atrophy is essential for maintaining metabolic health and normal life activities after SCI7
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