Abstract
Recently severe SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global COVID-19 pandemic. Systemic tracking algorithms of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographical levels, the shift occurred even in narrow scope of local epidemics. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have fitness advantage. Based on findings that the G614 variant grows to a higher titer as pseudo-typed virions. These findings illuminate changes important for mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions. Furthermore, predictive stewardship would be conducted for protection and limitation of transmissibility.
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