Abstract
Introduction: Cardiovascular events are the major cause of death in patients with chronic renal failure. About half of dialysis patients because of reduced phosphorus clearance have hyperphosphatemia. Hyperphosphatemia and following secondary hyperparathyroidism lead to some cardiovascular changes. Hemodialysis (HD) partly removes phosphorus during each dialysis session. Objectives: Presented study was designed to evaluate dialyzer variation effect on phosphorus level as a prognostic factor after dialysis using. Materials and Methods: Six kinds of dialyzer were used for dialysis; low flux (LF) dialyzer (F7 and F8), high flux (HF) dialyzer (F70 and F80) and finally hollow-fiber dialyzers including polyethersulfone (PES) 130 HF and polysulfone (PS) 13 LF. Fifty-seven patients were divided into 6 matched groups included three groups of 10 people and 3 groups of 9 persons in groups: A (F70), B (F80), C (F7), D (F8), E (PES 130 HF) and F (PS 13 LF). Patients were treated for one month with these dialyzers. At the end of the month, blood samples were taken again for phosphorus level before dialysis handling. Results: The mean pre-dialysis serum phosphorus was 5.03, 5.4, 5.2, 4.6, 4.95 and 5.1 mg/dl and the mean phosphorus was 5.43, 5.01, 4.9, 4.18, 4.17 and 5.3 mg/dl after one month of dialysis, respectively in groups A to F without any statistically differences between pre- and after one month dialysis values respectively. Discussion: The findings indicate dialyzer type in the control of serum phosphorus has not been effective in the short-term HD. We suggest a study with more duration time.
Highlights
Cardiovascular events are the major cause of death in patients with chronic renal failure which 10 to 30 times more inpatients with end-stage renal disease (ESRD) than others
Six kinds of dialyzer were used for dialysis; low flux (LF) dialyzer (F7 and F8), high flux (HF) dialyzer (F70 and F80) and hollow-fiber dialyzers including polyethersulfone (PES) 130 HF and polysulfone (PS) 13 LF
Phosphorus level values The values of pre-dialysis phosphorus level and corresponding values of phosphorus at the day of thirtieth after http://journalrip.com Journal of Renal Injury Prevention, Volume 5, Issue 2, June 2016
Summary
Cardiovascular events are the major cause of death in patients with chronic renal failure. About half of dialysis patients because of reduced phosphorus clearance have hyperphosphatemia. Objectives: Presented study was designed to evaluate dialyzer variation effect on phosphorus level as a prognostic factor after dialysis using. Cardiovascular events are the major cause of death in patients with chronic renal failure which 10 to 30 times more inpatients with end-stage renal disease (ESRD) than others. Despite traditional risk factors (diabetes, hypertension, hyperlipidemia, smoking, aging and male gender), non-traditional risk factors such as proteinuria, hypervolemia, anemia, vitamin D3 deficiency, hyper-homocysteinemia, malnutrition, thrombogenic factors, sleep disorders, hyperuricemia, chronic inflammation and hyperphosphatemia increase the risk of cardiovascular events and recently mentioned hyperphosphatemia, is a trouble in hemodialysis (HD) patients with own constitutional risk [1,2].
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