Bio-genic synthesis of ultra-small Au particles loaded silica nanoparticles for effective wound healing agent for the nursing care in the femoral fracture during surgery

Abstract

In this study, Au?SiO2 materials were synthesized by a simple biogenic approach using ultra-small Au nanoparticles (NPs) loaded on mesoporous SiO2 NPs. The functional groups, crystalline behavior, morphological structure, and elemental compositions of synthesized nanomaterials were characterized and confirmed by various techniques such as ultraviolet-visible (UV-Vis), X-ray diffraction (XRD) analysis, Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscope (TEM) with energy dispersive X-ray (EDX) mapping, Zeta potential, and dynamic light scattering (DLS) analysis. The cell viability results also indicated that the nano Au NPs loaded on mesoporous SiO2 NPs exhibited highly efficient biocompatibility and low toxicity. The wound healing rate of mesoporous SiO2 and Au?SiO2 NPs were 82% and 96%, respectively, at the end of 14 days, which were higher than that of the control samples. These results strongly support the possibility of using these Au particles loaded on mesoporous SiO2 NPs as a promising wound healing agent for nursing care during femoral fracture surgery.