Abstract
Objective: The present study was to synthesize nanoparticles using Manilkara hexandra stem bark extract its characterization and evaluating it by an antimicrobial and antioxidant assay.
 Methods: Manilkara hexandra stem bark silver nanoparticles (MHSB-AgNPs) was done by mixing silver nitrate (1 mmol) and aqueous stem bark extract and it was analyzed by UV-Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Zeta potential, Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive Spectroscopy (EDAX), Thermogravimetry/Differential Thermal Analysis (TG/DTA) and Differential scanning calorimetry (DSC). The antibacterial assay was done by a well diffusion method and also examined for antifungal assay was done by disk diffusion method and antioxidant potential Diphenyl-1-picryl hydrazyl (DPPH method)
 Results: Manilkara hexandra stem bark silver nanoparticles (MHSB-AgNPs) is characterized by various techniques such as UV-visible absorption spectrum ranges from 430 nm to 440 nm indicate silver nanoparticles. The Fourier Transform Infrared Spectroscopy consists of biomolecules acts as capping agent to form silver nanoparticles. Field Emission Scanning Electron Microscopy shows particle size ranges from 15 nm to 50 nm. Energy Dispersive Spectroscopy shows the presence of Silver. X-ray Diffraction corresponds to face-centered lattice planes (111), (200), (220) and (311). Dynamic Light Scattering show the range of 68 nm and Zeta potential show the negative value of-17 nm which has high stability. Silver nanoparticles is also examined by Thermogravimetry/Differential Thermal Analysis (TG/DTA) and Differential scanning calorimetry (DSC) this project the thermal stability of the nanoparticles. The aqueous stem bark is also examined by UV-visible absorption spectrum, Fourier Transform Infrared Spectroscopy (FTIR), and Gas Chromatography-Mass Spectrometry (GCMS). In GCMS 20 compounds were identified. Silver nanoparticles show high zone of inhibition in antimicrobial assays and act as a good antioxidant agent.
 Conclusion: It is eco-friendly, non-toxic, and it’s easy to synthesis and it shows good result in an antimicrobial and antioxidant assay can be applied in a pharmaceutical application.
Highlights
Indian tradition uses the medicinal plant as the predecessor for the development of the drug from the plant and is used in modern days
We identify biocompounds first by phytochemical screening and GC-MS for aqueous stem bark extract and we use centrifuge techniques to collect the silver nanoparticles
The Manilkara hexandra stem bark extract and MHSB-AgNPs were first determined by UV-visible spectrum wavelength ranging from
Summary
Indian tradition uses the medicinal plant as the predecessor for the development of the drug from the plant and is used in modern days. It is effective because of the bio-compounds present in it has no side effects and costs less [1]. The mixture of traditional and modern ideas produces a new source of active compounds which can be used as medicine with low side effects [2]. Silver nanoparticles in a biological approach involve microorganisms, plants, and viruses (or) their biomolecules [7]. Silver nanoparticles are currently applied in medicine, consumer products, even in surgical blades, catheters, and food packing [8]. The various parts of Manilkara hexandra contain medicinal values such as astringent, colic, dyspepsia, anorexia, leprosy, anthelmintic, refrigerant, hallucination, loss of consciousness, fermentation process etc. [10]
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