Biogenic Monoamines, Their Precursors, and Metabolites in the Brain of Rats under Experimental Circulatory Failure

Abstract

Abstract—The aim of the study was to establish the effect of experimental chronic circulatory failure on the levels of biogenic monoamines, their precursors, and their metabolites in rat brain structures. Thirteen weeks after experimental narrowing of the abdominal aorta to 1 or 0.7 mm, the levels of biogenic monoamines, their precursors, metabolites, kynurenine, and kynurenic acid were measured by reverse phase HPLC in rat brain structures. It was found that circulatory failure is accompanied by a decrease in the synthesis and functional activity of a mediator in the serotonergic system, which was evaluated using the level of the final metabolite 5-hydroxyindoleacetic acid. In the cerebral hemispheres, this may be partially related to deficiency of the precursor. The activation of kynurenic acid synthesis in the cerebral hemispheres and the brain stem is also likely. Changes in the indices that characterize central catecholaminergic systems were less pronounced.