Abstract
Alzet mini-osmotic pumps were implanted subcutaneously to administer norepinephrine (NE) and epinephrine (E) to 6-wk-old line UNH 105 chickens. Dose-time studies showed the most effective NE and E dose and exposure time on two chicken cellular immune responses: the phytohemagglutinin (PHA) wattle response and leukocyte migration. Administration of 1 μg/h NE for 72 h suppressed significantly the wattle stimulation index [2.48 ± .3 (SE)] compared to that of saline controls (4.1 ± .3) but enhanced mean leukocyte migration (7.7 ± .3 versus 4.9 ± .3). Epinephrine at 1 μg/h for 72 h significantly suppressed the wattle index (1.8±.2) compared to that of controls (2.8±.3) but E at 1 μg/h for 48 h enhanced leukocyte migration (9.5 ± .2 versus 6.4 ± .2). Continuous administration of NE and E at physiological levels alters cell-mediated immunity and appears to have an immune regulatory role in the chicken.
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