Abstract
Aim: To evaluate the apoptosis-inducing properties of undoped and silver-doped-zinc-oxide nanoparticles (SDZONs) synthesized using Boswellia serrata against MCF-7 (Luminal-A) and MDA-MB-231(Triple-negative) breast cancer cell lines.Methodology: Nanostructures were developed by facile biohydrothermal method and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR), and high resolutiontransmission electron microscopy (HR-TEM). The comparative effect of doping and dose concentration of nanostructures on cytotoxicity was measured using MTT and trypan-blue-exclusion assay.Results: SDZONs exhibited greater cytotoxicity (20.71%, 27.31% cell viability) as compared with undoped nanostructures (35.81%, 37.08% cell viability) against MCF 7 and MDA-MB-231, respectively.Conclusion: The activity of biogenic nanostructures was highly dependent on doping, dose, and type of cell lines used. The novel biogenic SDZONs could be exploited as a promising, cost-effective, and environmentally benign strategy to curb breast cancer.
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