Abstract
The brush border membrane (also designated microvillar, luminal, or apical membrane) is a highly ordered surface domain of transporting epithelial cells like small-intestinal enterocytes, large-intestinal colonocytes, or kidney proximal tubular cells. In the small intestine, the brush border membrane faces the intestinal lumen. Its microvilli provide a surface enlargement of approximately 20-fold as compared to a flat luminal cell surface. This membrane amplification serves the purpose of increasing the capacity of membrane-mediated digestion and carrier-mediated uptake.
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