Abstract
The bioflavonoid compounds—hesperidin methyl chalcone, orange bioflavonoid complex (OBC) D-2742, OBC 291-R-1, and OBC 291-Y-1, administered alone or in combination with ascorbic acid, were evaluated for antiulcer activity according to five different procedures for producing experimental ulcers: (I) depot histamine-induced gastric ulcers in the guinea pig, (II) reserpine-induced gastric ulcers in the seven and one-half hour pylorus ligated rat, (III) thermally induced serosal burn lesions in the rat stomach, (IV) ulcers induced by fifteen-hour pylorus ligation in the rat, and (V) gastric ulceration in the rat induced by repeated injections of reserpine. The combination of OBC 291-R-1 and ascorbic acid exhibited a greater trend than either agent alone in reducing the incidence of ulceration in procedure I. OBC 291-Y-1, ascorbic acid, and combinations of these two factors reduced the incidence of ulceration in procedure II. Neither the bioflavonoid compounds nor ascorbic acid alone or in combination were effective in reducing the degree of ulceration in the other three experimental procedures.
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