Abstract
Anti-inflammatory potential of orally administrated bioflavonoid-robinin, active sub-stance of original drug Flaroninum™ (FL), was investigated in the combination with methotrexate (MTX) and in monotherapy in rats suffering from adjuvant-induced arthritis (AA). Robinin (kaempferol-3-O-robinoside-7-O-rhamnoside) was isolated from the aerial parts of Astragalus falcatus Lam. The monotherapy with robinin was not efficient in alleviating symptoms of AA. The combination of MTX with robinin was similarly active as MTX alone in reducing the hind paw volume and change of body weight during the whole experiment. The combination, however, reduced plasma levels of Interleukin-17Aand activity of gamma-glutamyl transferase in joint more efficiently then MTX alone. Our results demonstrate that the novel combination of robinin and MTX mildly improved the reduction of inflammation in experimental arthritis.
Highlights
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, which preferably targets the synovial joints and is associated with premature mortality and socioeconomic burdens [1]
Robinin belongs to flavonoids, which are an essential group of naturally occurring polyphenolic compounds, widely distributed in the plant kingdom and exhibiting vast range of beneficial biological activities, including antiphlogistic action
Have examinedasthe administration of RBfor with antirheumatic of inflammatory processes that occur in RA and validating novel anti-inflammatory and Adjuvant arthritis is recognized as one of extensively used animal model for studyin anti-rheumatic drugs [20,21,26,27]
Summary
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, which preferably targets the synovial joints and is associated with premature mortality and socioeconomic burdens [1]. In addition to conventional disease-modifying antirheumatic drugs (DMARDs), that are associated with different side effects, targeted. Anti-inflammatory phytomolecules were shown to possess a wide scale mechanism of action including interactions with the inflammatory pathways [6,7]. Robinin belongs to flavonoids, which are an essential group of naturally occurring polyphenolic compounds, widely distributed in the plant kingdom and exhibiting vast range of beneficial biological activities, including antiphlogistic (antiinflammatory) action. These effects may interact directly with pro-inflammatory signal beneficial biological activities, including antiphlogistic (anti-inflammatory) action. Flavonoids may affec the function of enzyme systems critically involved in the generation o inflammatory processes, especially tyrosine and serine-threonine protein kinases [8,9]
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