Abstract
The present communication warrants the presence of significant wound healing bio-efficacy of aq. alc. extract of the seed (49.78%) of the plant Madhuca longifolia. A family of seven flavonoid fractions have been ascertained in the seed aq. alc. extract of the target plant using LCMS-8030 analysis. In vivo wound healing parameters (wound area, wound closure, epithelization period, skin breaking strength and hydroxyproline content) have been examined in Swiss albino mice models. Statistically significant (p < 0.001) enhancement in the wound healing bio-efficacy has been effectively induced using flavonoid-loaded gold: (Mlf@AuNps), silver: (Mlf@AgNps), and Au–Ag bimetallic: (Mlf@Au–AgNps) nanoparticles. Among the biofabricated nano-biomaterials, Mlf@AgNps exhibited an exceptional enhancement in the wound healing bio-efficacy (80.33%) attaining almost to the level of reference drug Placentrex (84.02%). All the fabricated nano-biomaterials were thoroughly characterized using UV–Vis, XRD, FE-SEM, TEM, EDX, and DLS. The promising enhancement in the wound healing potential of the nano-biomaterial (Mlf@AgNps) has been explained based on the cumulative effects of biological and nanotech parameters. The bio-fabricated (Mlf@AgNps) nano-biomaterials using the plant M. longifolia have lustrous prospects for the development of complimentary herbal nanomedicine for scaling-up the wound healing bio-efficacy.Graphical abstract
Highlights
The wound is a rupture in the epithelial integrity of the skinbased structural changes and functions of tissues
Seeds of the plant M. longifolia are used as folk medicine for skin-associated ailments which indicate the presence of medicinally important secondary metabolites
Scheme 1 Proposed chemical reaction of flavonoid fraction with Ag+ ions rendering the formation of Mlf@AgNps enzymatic interactions are associated with the generation of ATP formation (Klueh et al 2000)
Summary
The wound is a rupture in the epithelial integrity of the skinbased structural changes and functions of tissues. Impaired wound healing results in severe morbidity leading to long hospitalization of patients. There is always demand for treating wounds for minimization of the time taken for healing and to step down the risks of undesired complications (Ahmadi and Adibhesami 2017; Kandhasamy et al 2017). The use of conventional synthetic drugs over a long time is affiliated with side effects such as coma, hallucinations, kidney, heart, and liver failure (Biondi-Zoccai et al 2006). The use of plant-based nanomaterials has been accounted as a practical approach with improved physico-biochemical properties and functionality (Khoobchandani et al 2013; Katti 2016). The biogenic nanoparticles have shown promising potential as wound healing agents. The green nanotechnology is an open inquisitive field of research for the enhancement of bio-efficacy and has been exploited in the development of nanodrugs (Murugan et al 2015; Singh et al 2018)
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