BioEssays 9/2012

Abstract

BioEssaysVolume 34, Issue 9 Back CoverFree Access BioEssays 9/2012 First published: 14 August 2012 https://doi.org/10.1002/bies.201290042AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Chromosomal elements control replication timing, condensation and stability. Mammalian chromosomes contain three types of cis-acting elements, origins of replication, centromeres, and telomeres, that function to maintain their proper number and structure. On pages 760–770 of this issue Mathew Thayer reviews recent discoveries that suggest that mammalian chromosomes contain a fourth type of element, referred to as ‘inactivation/stability centers’. Disruption of these ‘inactivation/stability centers’ leads to late replication, an under-condensed state during mitosis, and unattached kinetochores during metaphase (red). Fully condensed chromosomes are shown in green and mitotic spindles are shown in blue. These new observations suggest that mammalian chromosomes contain four distinct types of cis-acting elements that function to ensure proper replication, condensation, segregation and stability of individual chromosomes. Backcover by M. Thayer Volume34, Issue9September 2012 RelatedInformation