Abstract
BioEssaysVolume 38, Issue 7 Cover PictureFree Access BioEssays 7∕2016 First published: 22 June 2016 https://doi.org/10.1002/bies.201670071AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract On pages 618–626, Schmidt et al. discuss the concept of cofactor squelching in light of recent evidence from genome-wide studies indicating that such competition for a limiting amount of coactivators is a general mechanism of transcriptional repression by signal-dependent transcription factors (TFs). They further discuss how TF cooperativity in so-called hotspots and super-enhancers may sensitize these enhancers to cofactor squelching. The cover illustrates how signal dependent TFs can be regarded as the ‘Robin Hoods’ of the genome, redistributing cofactors (gold coins) from the wealthy super-enhancers (stacks of gold coins). Cover design: Andreas N. Grøntved. Volume38, Issue7July 2016 RelatedInformation
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