BioEssays 4/2023

Abstract

BioEssaysVolume 45, Issue 4 2370031 COVER PICTUREFree Access BioEssays 4/2023 First published: 16 March 2023 https://doi.org/10.1002/bies.202370031AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Mediator is a multi-protein complex with essential roles in transcriptional regulation. In article 2200178 Hidehisa Takahashi and colleagues take a closer look at one of the subunits of this complex, namely MED26. MED26 is involved in recruiting the super elongation complex (SEC) to polyadenylated genes and little elongation complex (LEC) to non-polyadenylated genes. LEC recruitment is accompanied by the association between two nuclear bodies: Cajal bodies and histone locus bodies. Based on these observations, the authors hypothesize that MED26-containing Mediator, via its disordered region, orchestrates multiple transcription processes through the organization of nuclear bodies. Volume45, Issue4April 20232370031 RelatedInformation