Abstract
Cover Photograph: Controlling the mitochondrial collective. On pages 958–966 of this issue Emelie Braschi and Heidi McBride draw comparisons between mitochondria and the Borg, a fictional humanoid species from the Star Trek television series. Both entities constitute a unified collective (or interconnected reticulum) where decisions are either made locally within their network (or “hive”) or globally within the “subspace domain”. For mitochondria, local control involves fusion, regulated by distinct GTPases, and fi ssion leading to depolarization of one of the “daughter” mitochondria and hyperpolarization of the other. On the other hand, the reticulum is highly responsive to the subspace domain, taking into account signaling pathways and coupling them with complex cellular transitions including developmental cues, mitosis and apoptosis. The cover photograph shows a photomontage of labeled mitochondria of a COS7 cell on a stellar background.
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