Abstract
Ferritin naturally exists in most organisms and can specifically recognize the transferrin 1 receptor (TfR1), which is generally highly expressed on various types of tumor cells. The pH dependent reversible assembling and disassembling property of ferritin renders it as a suitable candidate for encapsulating a variety of anticancer drugs and imaging probes. Ferritins external surface is chemically and genetically modifiable which can serve as attachment site for tumor specific targeting peptides or moieties. Moreover, the biological origin of these protein cages makes it a biocompatible nanocarrier that stabilizes and protects the enclosed particles from the external environment without provoking any toxic or immunogenic responses. Recent studies, further establish ferritin as a multifunctional nanocarrier for targeted cancer chemotherapy and phototherapy. In this review, we introduce the favorable characteristics of ferritin drug carriers, the specific targeted surface modification and a multifunctional nanocarriers combined chemotherapy with phototherapy for tumor treatment. Taken together, ferritin is a potential ideal base of engineered nanoparticles for tumor therapy and still needs to explore more on its way.
Highlights
Significant progress has been made in the diagnosis and treatment of cancer over the past few decades
The nanoparticle drug delivery system which approved for clinical use on present market are limited mainly including liposomal doxorubicin (DOX) and albumin-paclitaxel (Abraxane)
The above nanodrug delivery system only relies on passive targeting, which can reduce toxic and side effects very well, but it does not produce significant improvement in the therapeutic index [8,9]
Summary
Significant progress has been made in the diagnosis and treatment of cancer over the past few decades. The above nanodrug delivery system only relies on passive targeting, which can reduce toxic and side effects very well, but it does not produce significant improvement in the therapeutic index [8,9] Under such circumstances, there is an urgent requirement to develop drug nanocarriers with high biocompatibility and tumor targeting ability. Strong tumor targeting ability: ferritin drug carrier mainly including:. Strong tumor targeting ability: ferritin has the has the enhanced permeability and retention (EPR) effect of general nanocarriers, but enhanced permeability and retention (EPR). Effect of general nanocarriers, and has the has the ability to naturally target tumor cells and be enriched at the tumor site. Introduce themodification favorable characteristics of ferritin ferritin drug carriers,This the review specificwill targeted surface and a multifunctional nanocarriers chemotherapy with modification phototherapyand for atumor treatment. Introduce themodification favorable characteristics of ferritin ferritin drug carriers,This the review specificwill targeted surface and a multifunctional nanocarriers chemotherapy with modification phototherapyand for atumor treatment. nanocarridrug carriers,combined the specific targeted surface multifunctional ers combined chemotherapy with phototherapy for tumor treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
