Abstract
1. 1. DDT is able to stimulate heat production in rats independently on central thermal receptors. 2. 2. Chlorpromazine and imipramine decreased the hyperthermic effect of DDT on intact as well as decapitated rats. 3. 3. DDOH blocked completely oxygen consumption by mitochondria pretreated with chlorpromazine or imipramine. 4. 4. DDOH reversed the passive swelling of mitochondria induced by chlorpromazine or imipramine in KCl and NaCl solutions. 5. 5. Dearrangement of mitochondrial membrane permeability to osmotically active cations as a mode of anti-hyperthermic action of chlorpromazine or imipramine on peripherial heat production stimulated by DDT is discussed.
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