Abstract
One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its controversial results and complicated control. One of the solutions is concentrating the electromagnetic energy nanoscopically on the parts of the malignant cells instead of heating up the complete tumor-mass. This approach is a kind of non-uniform energy absorption, providing energy liberation only in the selected regions. The energy-absorption of the malignant cells targets the membranes and creates a situation far from thermal equilibrium. The selection of the malignant cells is based on their decided differences from their healthy counterparts. The distinguishing parameters are the electromagnetic properties of the components of the malignant tissue which are the physiologic differences between the malignant cells and their healthy counterparts. The targets realize nano-range heating, using natural nanoclusters on the cell-membrane without artificially implementing them. This energy absorption generates consequent reactions, like programmed cell-death (apoptosis) continued by immunogenic cell-death involving extended immune reactions. The applied radiofrequency current is amplitude modulated by time-fractal modulation pattern. The accurately matched impedance realizes the self-selective mechanisms which are promoted by stochastic resonances. This complex method is a new kind of hyperthermia, named mEHT. Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology.
Highlights
IntroductionModern hyperthermia treatments in oncology use electromagnetic effects overheating the living object completely (whole body) or partly (regionally or locally)
Hyperthermia ChallengesModern hyperthermia treatments in oncology use electromagnetic effects overheating the living object completely or partly
Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology
Summary
Modern hyperthermia treatments in oncology use electromagnetic effects overheating the living object completely (whole body) or partly (regionally or locally). Oncological hyperthermia is intended to be an ideal combination therapy; it provides synergies with most of the conventional treatment modalities, boosts their efficacy and helps to desensitize the previously non-effective treatments. The history of hyperthermia in oncology has been hectic and controversial [1]. The general professional skepticism blocked its application for a long time. Hyperthermia is a constrain energy-delivery, forcing the homeostatic equilibrium to change. From this point the control of the processes became complicated. The adequate dose and protocol of the method and the reproducibility of the results are a complex task; its thermal status is far from equilibrium
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