Abstract
BackgroundDuchenne muscular dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition.ObjectiveThis study aimed to describe and evaluate bioimpedance parameters in boys with DMD.DesignThis cross-sectional, descriptive study investigated children and adolescents diagnosed with DMD. Age, weight, height, resistance, and reactance data were collected. Phase angle and bioelectrical impedance vector analysis were calculated based on resistance and reactance values.ResultsWe analyzed 43 boys aged between 2.7 and 19.8 years. Low-phase angle values were observed during the investigation of bioimpedance parameters. Bioelectrical impedance vector analysis showed that approximately 87% of the subjects presented vectors outside the tolerance ellipses, and only one patient presented vectors located within the 50% tolerance ellipse, indicating normally hydrated and a good body cell mass. Compared with the reference population, boys with DMD had lower levels of body cell mass.ConclusionBased on the evidence, compared with the reference population, patients with DMD had lower levels of body cell mass. This evidence points to bioimpedance parameters as useful tools for the nutritional evaluation and clinical management of patients with DMD.
Highlights
Duchenne muscular dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition
Bioelectrical impedance vector analysis showed that approximately 87% of the subjects presented vectors outside the tolerance ellipses, and only one patient presented vectors located within the 50% tolerance ellipse, indicating normally hydrated and a good body cell mass
Sampling included all patients with DMD under 20 years of age treated at the neurology outpatient facility at the Onofre Lopes University Hospital, Brazil, who were attended by the nutrition team between September 2016 and December 2018 and underwent Bioelectrical impedance analysis (BIA)
Summary
Duchenne muscular dystrophy (DMD) is a disease characterized by progressive loss of functional muscle mass followed by changes in body composition. Objective: This study aimed to describe and evaluate bioimpedance parameters in boys with DMD. Phase angle and bioelectrical impedance vector analysis were calculated based on resistance and reactance values. Low-phase angle values were observed during the investigation of bioimpedance parameters. Compared with the reference population, boys with DMD had lower levels of body cell mass. Conclusion: Based on the evidence, compared with the reference population, patients with DMD had lower levels of body cell mass.
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