Abstract
PEGylated PPI dendritic scaffold was used for the delivery of an anti-leukemic drug, Prednisolone. The current study evolves and emerges the use PEGylated poly dendritic scaffold for the delivery of this drug. In this the prednisolone was loaded and synthesized with PEGylated PPI dendritic scaffold. Estimated the biodistribution of prednisolone in different vital organ was carriedout by HPLC method and the study was promising the distribution of drug candidate.
Highlights
Dendrimer is a polymeric material, which is of novel type
As a synthetic glucocorticoid (GC), its lipophilic structure allows for easy passage through the cell membrane where it binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm
Complex binding to positive glucocorticoid response elements (GREs) leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes [7]
Summary
Dendrimer is a polymeric material, which is of novel type. Uniqueness in the structure, molecular weight and shape having high degree of control, are the parameters, which led to the synthesis of unimolecular micelles [1,2,3,4]. By molecular simulation many dendrimers have been synthesized fairly on a large scale and are characterized experimentally [5]. These possible applications of the polypropylene imine dendrimers are generally based on the following characteristics: larger number of readily accessible end groups; regular size and shape; either nitrile or amine; possibility of end group modification in order to tailor properties such as reactivity, toxicity, solubility, stability, temperature, polyelectrolyte character, glass transition and possibility of encapsulating guest molecules [6]. Formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes [7]
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