Abstract
ABSTRACTThis paper investigates the influence of total gastrectomy, with and without a jejunal pouch, on the biodistribution of the radiopharmaceutical Technetium-99m pertechnetate (99mTcO4−). A quantitative biodistribution study was performed on the 30th postoperative day in Wistar rats, using the Wizard PerkinElmer gamma counter. The percentage of injected radioactivity of 99mTcO4− per gram of tissue (% ATI/g) in Roux-en-Y total gastrectomy rats was lower in the lung, brain, and femur, compared to the sham rats (p <.05). In the jejunal pouch rats, the%ATI/g was higher than in the jejunum of sham rats (p <.05). The biodistribution was higher in the lung, brain, and femur of Roux-en-Y pouch rats than in Roux-en-Y rats (p <.05). Serum levels of cobalamin, phosphorus, and calcium were lower in gastrectomized than in sham rats (p <.05). No significant histological change was observed in the jejunum of Roux-en-Y rats. In the jejunal pouch, we found vascular ingurgitation, inflammation, submucosal, and muscular wall hypertrophy and widening of the villi. In conclusion, total gastrectomy in rats affected the biodistribution of 99mTcO4− to important organs, mainly when a Roux-en-Y reconstruction without a pouch was performed. Moreover, the operation caused biodistribution-related metabolic changes.
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