Abstract
Titanium dioxide nanoparticles (TiO2-NPs) are widely used in many fields. The bio-distribution and toxicology of different sizes (25 nm and 50 nm) of TiO2-NPsin vivois evaluated in this paper. The results of quantitative distributionin vivoshow that it is difficult for TiO2-NPs to excretion clearly from tissues and organs. At the endpoint of experiment of different groups, there are still many TiO2-NPs located in the main organs such as spleen, liver and lung after 120 days. Blood biochemical parameters keep unchanged compared with control group. However, pathological results show that lesions in spleen, liver and lung where TiO2-NPs particles are mainly accumulated and retained are getting serious with the time prolonging. The results indicate that TiO2-NPs are low toxic to mice but may have some potential effects on liver and kidney functions after exposure long time. The fundamental importance information gained from such a study will give the guidance on the application of TiO2-NPs.
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