Abstract
Random copolypeptides (PHEDLG) consisting of N-hydroxyethyl- d-glutamine (HEDG) and N-hydroxyethyl- l-glutamine (HELG) covering the whole range of d, l-copolymer composition were prepared by carrying out aminolysis reactions with 2-amino-1-ethanol ( E) on starting random copolymers consisting of γ-methyl- d-glutamate and γ-methyl- l-glutamate (PMDLG). The effects of copolymer composition and sequential distributions on the rate of hydrolysis by bromelain in a pseudo-extracellular fluid (PECF) at pH 7.4 and 37.0°C simulated in vivo polymer degradation. Degradation data for these samples followed the Michaelis–Menten rate law, being of the first order to the enzyme concentration. It was shown that the rate of degradation by bromelain was controlled by comonomer composition as well as sequential distributions of comonomers in the copolymer chains.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
