Abstract
Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The in vitro and in vivo degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced in vitro and in vivo biocompatibility along with promising antibacterial properties.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
