Biodegradable suture threads as controlled drug delivery systems

Abstract

ABSTRACTChitosan yarns, which could be used as surgical suture threads that potentiate the healing process by releasing N-acetyl-D-glucosamine (GlcNAc), were developed using the wet spinning method. Scanning electron microscopy and mechanical traction tests were performed, followed by biodegradation and in vitro release tests. Morphologically, the yarns were cylindrical and well defined. During tensile tests, a decrease in the mechanical properties of the wires was observed owing to the addition of GlcNAc; however, the mechanical properties remained consistent with the specifications of the US Pharmacopeia. It was also determined that GlcNAc accelerated the degradation process of chitosan. The release of GlcNAc occurred slowly during the first 14 days of the in vitro release tests, and more rapidly thereafter. Thus, this study indicated that the wet spinning technique was effective for obtaining chitosan suture threads, which could be promising controlled drug delivery systems.