Biodegradable silk-curcumin composite for sustained drug release and visual wound monitoring

Abstract

The production of biodegradable dressing capable of sustained drug release, along with the monitoring of wound conditions, represents new heights of multifunctional platforms for wound care. The reported curcumin-loaded silk fibroin has shown sustained drug release over the time of 10 days through a non-Fickian diffusion process satisfying Korsmeyer-Peppas' model along with the visual monitoring of wound healing through notable color variation with pH as a biomarker. The superhydrophobic nature (water contact angle = 163.7) of the SF, along with the lipophilicity (CA = 0 (Blood)) and hygroscopic nature prevents wetting of wound surface, whereas the excess exudates from wounds are absorbed along with sufficient water and oxygen permeability. The pH responsiveness as a result of the keto-enol tautomerism in curcumin was utilized for wound monitoring through visual indication enabling even ordinary people to detect the state of the wound. The in-situ biodegradation studies verified using cow-dung slurry, the degradability of the material with 25.3% weight loss within 30 days following first-order kinetics (R2 = 0.994), as a result of the attack of proteolytic enzymes on the amino acid units of SF, mitigating the concerns of medical wastes.