Abstract
Biodegradable polymeric nanoparticles are employed as templates for the biomimetic mineralization of CaP in the aqueous phase. Particles in the sub-µm range were prepared by a combination of solvent evaporation and miniemulsion techniques. The synthesized particles were subjected to degradation via random saponification. The anionic functional groups produced as a consequence of degradation due to production (ultrasonication step) and post treatment (hydrolysis) steps are used for the CaP mineralization. The composite particles were studied using HRSEM, TEM, and XRD. These polymer/CaP composite nanoparticles have a great potential to be used as a regenerative filler or as a scaffold for nucleation and growth of new bone material.
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