Biodegradable multifunctional bioactive Eu-Gd-Si-Ca glass nanoplatform for integrative imaging-targeted tumor therapy-recurrence inhibition-tissue repair

Abstract

• A multifunctional bioactive tumor imaging-targeted therapy-repair nanoplatform was constructed. • The nanoplatform showed targeted tumor imaging and therapy. • The nanoplatform efficiently inhibited tumor recurrence and enhanced tissue regeneration. The postoperative tissue healing of tumor excision, monitoring of remained tumor cells and inhibiting of tumor recurrence are still the great challenge. Herein, we develop a multifunctional biodegradable silicon-based Eu-Gd-Si-Ca bioactive glass nanoplatform (MBSGN) for tumor imaging, inhibiting tumor recurrence and enhancing tumor-impaired tissue regeneration. MBSGN exhibited a branched mesoporous structure (10–20 nm), controlled biodegradation, ultrahigh drug loading (602.52 mg g −1 ) and pH responsive release behavior, special magneto-optical properties and tumor cell-targeted surface. MBSGN possessed excellent biocompatibility and tumor cell-targeted capacity in vitro . MBSGN showed multi-model bioimaging capacity for skin tumor tissue (fluorescence/magnetic resonance/computed tomography imaging). MBSGN could efficiently eliminate the tumor growth, inhibit the local tumor recurrence through in situ removal of residual tumor cells, greatly enhance the full-thickness wound healing and tumor surgery-caused wounds repair. This study offers a reasonable and promising pathway for in situ integration of multi-modal bio-imaging, recurrent melanoma therapy and tissue regeneration.