Abstract
“Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.
Highlights
Since the first biodegradable stent[9] in the 1990s, attempts have been made to develop such stents for cardiovascular applications[10,11,12]
The biodegradable rapamycin-eluting stent that we developed in this study is designed to be expanded by a balloon, and has a self-locking characteristic which can avoid stent recoil resulted from polymer properties and the external pressure of the arteries
The experimental results of this study indicated that the biodegradable stents could release an effective and high concentration of rapamycin for over 4 weeks
Summary
Since the first biodegradable stent[9] in the 1990s, attempts have been made to develop such stents for cardiovascular applications[10,11,12]. Clinical trials show that those with a biodegradable vascular scaffold have a greater incidence of incomplete strut apposition and tissue prolapse area. Edge dissection and stent strut fracture may occur, leading to acute stent thrombosis and even death. Hybrid biocompatible nanofiber drug-eluting polymers on BMS and biodegradable-polymer stents have been developed for the application of drugs to repair denuded arteries[20,21,22]. A cable-tie poly-L-lactide (PLLA) stent loaded with rapamycin-eluting poly (lactic-co-glycolic acid) (PLGA) nanofibers was developed to treat denuded rabbit arteries
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
