Biodegradable bone substitute based on keratin biopolymer

Abstract

Event Abstract Back to Event Biodegradable bone substitute based on keratin biopolymer George Dias1 and Azam Ali2* 1 University of Otago, Anatomy, New Zealand 2 University of Otago, Applied Science, New Zealand Biodegradable materials that degrade after fulfilling their function are significant in orthopaedics field. Keratin, a structural protein abundant in wool & hair, is ideally suited for the development of such materials through a combination of tough physical properties and rich chemical biological functionality. The author’s group have shown that keratin is a versatile biocompatible biopolymer and can be used to produce matrices with a wide range of forms and potential functions. Porous keratin hydroxyapatite constructs where prepared with pore structure compatible to bone and a 3mm defect in sheep tibia was used as an in vivo model. Histological examination revealed that the constructs were highly biocompatible. The nature of the cellular response to the implants was similar to the mechanism by which autologous bone is osseointegrated. This suggests that keratin have the potential to perform in applications where autologous bone is currently used. Keywords: biomaterial, Biocompatibility, Bone repair, Biodegradable material Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Naturally-derived materials and biopolymers Citation: Dias G and Ali A (2016). Biodegradable bone substitute based on keratin biopolymer. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01959 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Azam Ali, University of Otago, Applied Science, Dunedin, New Zealand, azam.ali@otago.ac.nz Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers George Dias Azam Ali Google George Dias Azam Ali Google Scholar George Dias Azam Ali PubMed George Dias Azam Ali Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.