Biodegradable bicomponent fiber stents with core/sheath configuration using polydioxanone and poly-L-lactic acid

Abstract

Event Abstract Back to Event Biodegradable bicomponent fiber stents with core/sheath configuration using polydioxanone and poly-L-lactic acid Junsik Son1, Young Jae Lee2, Jae Ha Park2, Tae-Yub Kwon3 and Seok Hwa Choi4 1 Korea Textile Development Institute, High-Tech Fiber R&D Headquarters, Korea 2 S&G BIOTECH INC, Korea 3 Kyungpook National University, Dental Biomaterials, Korea 4 Chungbuk National University, Veterinary Medical Center, Korea Biodegradable stents can alleviate intestinal obstruction and stenosis in patients. The goal of the present study was to develop a novel biodegradable sheath/core bicomponent monofilament fiber stents using polydioxanone (PDO) as sheath material and poly-L-lactic acid (PLLA) as core material by melt spinning process. Parameters that guarantee stable processing of PDO and PLLA during coaxial extrusion with different core/sheath volume ratios were explored (Fig. 1). The stents were designed into tubular shape using a braided machine. The dimensions of the PDO/PLLA sheath-core braided stent were 90 mm in length and 15 mm in radius (Fig. 2). Microscopic studies of the PDO/PLLA sheath-core monofilaments showed that diameter of monofilament was 0.40 mm and diameter of PLLA of core that ranged from 100 to 200 µm. The tensile strengths of the PDO/PLLA sheath-core monofilaments were higher than 3 gf/d and elongation at break were lower than 30%. The physical properties such as biodegradation behaviors, deploy force, radial force and others of PDO/PLLA sheath-core braided stent were also investigated. In conclusion, this biodegradable PDO/PLLA sheath-core bicomponent stent can find valuable applications in treatment of intestinal obstruction and stenosis clinically. This research was financially supported by the “Advanced medical new material (fiber) development program” through the Ministry of Trade, Industry & Energy (MOTIE) and Korea Institute for Advancement of Technology (KIAT) (R0002647). Keywords: Functionalization, biomedical application, tissue compatibility, biodegredation Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biocompatibility of nanobiomaterials Citation: Son J, Lee Y, Park J, Kwon T and Choi S (2016). Biodegradable bicomponent fiber stents with core/sheath configuration using polydioxanone and poly-L-lactic acid. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00964 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Junsik Son Young Jae Lee Jae Ha Park Tae-Yub Kwon Seok Hwa Choi Google Junsik Son Young Jae Lee Jae Ha Park Tae-Yub Kwon Seok Hwa Choi Google Scholar Junsik Son Young Jae Lee Jae Ha Park Tae-Yub Kwon Seok Hwa Choi PubMed Junsik Son Young Jae Lee Jae Ha Park Tae-Yub Kwon Seok Hwa Choi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.