Abstract
In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.
Highlights
Biodegradable polymers are successfully used in medicine due to their ability to adjust properties, such as molecular weight, local microstructure, degradation rate, mechanical strength and stiffness
To date, the overwhelming majority of works devoted to silatranes are focused on the biological activity of low molecular weight compounds
The results obtained in this study show the possibility of creating biodegradable and biocompatible amphiphilic polymers containing silatrane groups
Summary
Biodegradable polymers are successfully used in medicine due to their ability to adjust properties, such as molecular weight, local microstructure, degradation rate, mechanical strength and stiffness. These polymers can be used singly or as composites. One of the very important biomedical applications of such polymers is the preparation of colloidal drug delivery systems. With advantages, such as increased solubility, bioavailability, and the ability to target drug delivery and release to specific locations, this drug transport method is at the forefront of current research [3]. There are practically no publications on the biological activity of silatrane-containing polymers
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