Abstract
Human cytomegalovirus (HCMV) retinitis treated with frequent intraocular injections of ganciclovir is associated with complications such as endophthalmitis, retinal detachment and vitreous haemorrhage. Several formulations of biodegradable injectable PLGA microspheres with ganciclovir have been previously investigated as a possible alternative for treatment of HCMV retinitis. This report describes two new formulations of PLGA microspheres with ganciclovir that also include alpha tocopherol (vitamin E) or glyceryl tricaprylate/caprate (miglyol) as additives, modulating the release rate of ganciclovir. While additive free microspheres in vitro released about 90% of its ganciclovir within 20 days, the microspheres with the additives released only 20% of the drug during this period, and continued releasing the drug at the same rate for a total of 42 days. Keywords: cytomegalovirus retinitis, ganciclovir, alpha tocopherol, glyceryl tricaprylate/caprate, microspheres, intravitreal administration
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
